Table 2

Gene-edited farm animals with improved production performance

Species Gene Modification Approach Reference
Pig MSTN Knock-out ZFNs [18]
Pig MSTN Knock-out CRISPR/Cas9 [36]
Pig MSTN Knock-out CRISPR/Cas9 and Cre/loxP [37]
Pig MSTN Knock-out CRISPR/Cpf1 [38]
Pig MSTN Knock-out TALENs and CRISPR/Cas9 [39]
Pig IGF2 Knock-out CRISPR/Cas9 [54,55]
Pig FBXO40 Knock-out CRISPR/Cas9 [58]
Sheep MSTN Knock-out CRISPR/Cas9 [43]
Rabbit MSTN Knock-out CRISPR/Cas9 [44]
Goat MSTN Knock-out CRISPR/Cas9 [44,45]
Cattle MSTN Knock-out ZFNs [46]
Chicken MSTN Knock-out D10ACas9 [47]
Chicken G0S2 Knock-out CRISPR/Cas9 [50]
Quail MSTN Knock-out CRISPR recombinant adenovirus [48,49]

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