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All issues Volume 2 / No 5 (2023) Natl Sci Open, 2 5 (2023) 20220066 Full HTML

Table 3

Gene-edited animal models of disease resistance

Species Gene Disease/Traits Modification Reference
Pig CD163 Porcine reproductive and respiratory syndrome (PRRS) Mutant [66,67]
Pig CD163 Porcine reproductive and respiratory syndrome (PRRS) Knock-out [68–71]
Pig CD163 Porcine reproductive and respiratory syndrome (PRRS) Homologous replacement [72,73]
Pig Sn/SIGLEC1/CD169 Porcine reproductive and respiratory syndrome (PRRS) Knock-out [75]
Pig ANPEP Transmissible gastroenteritis virus (TGEV)/porcine epidemic diarrhea virus (PEDV) Knock-out [79–81]
Pig ANPEP Porcine delta coronavirus (PDCoV) Knock-out [82]
Pig CMAH Porcine epidemic diarrhea virus (PEDV) Knock-out [84]
Pig shRNA Classical swine fever virus (CSFV) Knock-down [86,87]
Pig pRSAD2 Classical swine fever virus (CSFV)/pseudo rabies virus (PRV) Knock-in [88]
Pig shRNA Pig foot-and-mouth disease virus Knock-down [89]
Sheep shRNA-VP1 Sheep foot-and-mouth disease virus Knock-down [90]
Bovine shRNA-VP1 Bovine foot-and-mouth disease virus Knock-down [91]
Bovine NRAMP1 Bovine tuberculosis Knock-out [93]
Bovine SP110 Bovine tuberculosis Knock-out [92]
Bovine CD18 Bovine pneumonia Mutant [94]
Bovine PRNP Bovine spongiform encephalopathy Knock-out [100,101]
Bovine PRNP Bovine spongiform encephalopathy Knock-in [101]
Chicken ANP32 Avian influenza virus (aivs) Knock-out [102]
Chicken 3D8 scFv Avian influenza virus (aivs) Knock-in [103]
Chicken Tva Avian leukemia virus (ALV)-A/K Knock-out [104]
Chicken NHE1 Avian leukemia virus (ALV)-J Mutant [20,105]
cow HSPA1L Heat resistant cow Mutant [107]
Pig ANTXR1 Porcine vesicular disease (Seneca virus A) Knock-out [106]
Sheep TLR4 Improve sheep disease resistance Transgene [108]

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