Table 1
Genes related to long-term survival and normal function maintenance of transplated organs
| Gene and protein | The types of modification required and protein expression | |
| Xenoreactive genes | Pig GGTA1 | Knockout |
| Pig CMAH | Knockout | |
| Pig β4GalNT2 | Knockout | |
| Complement regulate proteins | Human CD46 | Expression |
| Human CD55 | Expression | |
| Human CD59 | Expression | |
| Coagulation regulates proteins | Human TBM | Expression |
| Human EPCR | Expression | |
| Human TFPI | Expression | |
| Human vWF | Partial replacement | |
| Pig vWF | Knockout | |
| Human CD39 | Expression | |
| Anti-inflammatory proteins | Human HO-1 | Expression |
| Human A20 | Expression | |
| shTNFRI-Fc | Expression | |
| Macrophage regulation proteins | Human CD47 | Expression |
| Human CD24 | Expression | |
| Human IL-10 | Expression | |
| T cell regulation proteins | Pig B2M | Knockout |
| Pig CIITA | Knockout | |
| Human B2M | Expression | |
| Human CIITA-DN | Expression | |
| Human CTLA4-Ig | Expression | |
| Human PD-L1 | Expression | |
| NK cell regulation proteins | Pig ULBP1 | Knockout |
| Human HLA-E | Expression | |
| Human HLA-G | Expression | |
| Functional proteins | Human Renin | Replacement |
| Human EPO | Replacement | |
| Human insulin | Replacement | |
| Human serum albumin | Replacement | |
| Growth hormone receptor | Knockout for reduction of porcine organ size | |
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