| Issue |
Natl Sci Open
Volume 2, Number 5, 2023
Special Topic: Gene Editing towards Translation
|
|
|---|---|---|
| Article Number | 20220061 | |
| Number of page(s) | 18 | |
| Section | Life Sciences and Medicine | |
| DOI | https://doi.org/10.1360/nso/20220061 | |
| Published online | 07 August 2023 | |
REVIEW
Treatment of infectious diseases by in vivo gene editing
1
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China
2
Yoltech Therapeutics, Shanghai 200241, China
* Corresponding author (email: yxwu@bio.ecnu.edu.cn)
Received:
25
November
2022
Revised:
5
January
2023
Accepted:
17
January
2023
Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) nuclease systems. It is a promising tool for the development of new treatment strategies for infectious diseases. Due to its higher editing efficiency and lower off-target effect, gene editing therapy mainly uses CRISPR Cas-derived tools to resist viral and non-viral infections. Here, we reviewed the recent research progress of gene editing in antiviral therapy (human immunodeficiency virus, hepatitis B virus, severe acute respiratory syndrome coronavirus 2, and human papillomavirus) and inhibition of infectious diseases that involve bacteria, fungi and parasites.
Key words: gene editing / in vivo therapy / CRISPR-Cas / infectious diseases / viral infection
© The Author(s) 2023. Published by Science Press and EDP Sciences.
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