Overview of single-cell Omics methods. Numerous single-cell technologies have been developed to profile genome (red), epigenome (blue), transcriptome (orange), and proteome (green), respectively. The distance from the center of a circle to the edge indicates the year from 2010 to now. The references (PMIDs) for corresponding methods are listed below. Smart-seq3xpress, 35637418. FLASH-seq, 35637419. VASA-seq, 35760914. Smart-seq3, 32518404. Smart-seq-total, 34911763. ScISOR-seq, 30320766. SPLiT-seq, 29545511. Sci-RNA-seq3, 30787437. 10x Chromium, 28091601. MATQ-seq, 31028632. Seq-Well, 28192419. Sci-RNA-seq, 28818938. Smart-seq2, 24056875. InDrop, 26000487. Drop-seq, 26000488. MARS-seq, 24531970. Smart-seq, 22820318. CEL-seq, 22939981. Single cell RNA-seq, 19349980. SMAC-seq, 32042188. Small-seq, 30250291. Small RNA transcriptome sequencing, 27798564. SCoPE2, 33504367. SCoPE-MS, 30343672. ScWB, 24880876. CyTOF, 24584119. Proteomic chip, 22203961. Microchip platform, 23998271. META-CS, 33593904. S3-WGS, 34226710. LIANTI, 28408603. eMDA, 26340991. MALBAC, 23258894. DOP-PCR, 1639399. MDA, 11381035. EpiDamID, 35366395. CoBATCH, 31471188. itChIP, 31481796. CUT&Tag, 31036827. scChIP-seq, 26458175. scDamID, 26257285. scHi-C, 24067610. scATAC-seq, 26083756. scDNase-seq, 26605532. scNome-seq, 28653622. Single-nucleus Hi-C, 28355183. sciHi-C, 28135255. scMNase-seq, 30258225. Dip-C, 30166492. s3-ATAC & s3-GCC, 34226710. CAP-C, 32839564. scSPRITE, 34426703. scRRBS, 25837417. scBS-seq, 25042786. scAba-seq, 27347753. scCGI-seq, 28126923. snmC-seq, 28798132. sci-MET, 29644997.