REVIEW

T cell receptor signaling and cell immunotherapy

¹ Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
² State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China

^* Correspondence authors (emails: cqxu@sibcb.ac.cn (Chenqi Xu); xs.shi@siat.ac.cn (Xiaoshan Shi))

Received: 23 December 2023
Revised: 25 February 2024
Accepted: 14 March 2024

Abstract

As the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells. Understanding the mechanisms of TCR signaling has led to the development of engineered T cell therapies, which have extensive applications in the treatment of diseases such as cancer, infection and autoimmunity. Here, we review the current understanding of antigen-induced TCR signaling and discuss its applications in T cell therapies.