Mechanisms regulating the tumor-infiltrating DC maturation. Tumor cells, CAFs, and tumor-infiltrating microbes inhibit the maturation of tumor-infiltrating DCs by regulating metabolism, etc. The effector T cells and NK cells in the tumor microenvironment promote the generation of LAMP3⁺ DCs by producing chemokines and IFNs, and immunosuppressive cells such as Tregs inhibit the generation of LAMP3⁺ DCs by producing IL-10 and TGF-β. The efficacy of radiotherapy and other treatments also depends on the induction of LAMP3⁺ DCs. The efficacy of radiotherapy, chemotherapy and immunotherapy is also dependent on their induction of LAMP3⁺ DCs.